Khan SU, Anderson BD, Heil GL, Liang S, et al. A Systematic Review and Meta-Analysis of the Seroprevalence of Influenza A (H9N2) Virus Infection Among Humans. J Infect Dis 2015.
INTRODUCTION: ?Given that Influenza A (H9N2) subtype viruses are recognized as a pandemic threat, we evaluated the overall burden of H9N2 infections among avian-exposed human populations.
METHODS: ?We performed a systematic literature search in PubMed, AGRICOLA, and Cab Abstracts databases from 1997 to 2013. Studies reporting serological evidence of human Influenza A(H9N2) infection among avian-exposed populations were included. We used a WHO-recommended case definition for serological evidence of infection through hemagglutination inhibition (HI) and microneutralization (MN) assays. We calculated overall seroprevalance through a random effects meta-analysis model.
RESULTS: ?Seroprevalence figures reported by the studies ranged from 1% to 43% (median: 9%) by HI, which was not significantly different from the seroprevalence estimated through the WHO-recommended case definition (median: 1.3%, range:0.5%-42.6%). Reported seroprevalence by MN ranged from 0.6% to 9% (median: 2.7%), which was greater than the seroprevalence estimated through the WHO-recommended case definition (median: 0.3%, range: 0.1%-1.4%).
CONCLUSION: ?A small proportion of avian-exposed humans had evidence of H9N2 infection. As the virus has a near global distribution in poultry, it seems likely that present surveillance efforts are missing mild or asymptomatic infections among avian-exposed persons. It seems prudent to closely monitor avian-exposed populations for H9N2 infection to provide pre-pandemic warnings.
See Also:
Latest articles in those days:
- Development and evaluation of a multiplex real-time RT-PCR assay for simultaneous detection of H5, H7, and H9 subtype avian influenza viruses 12 hours ago
- Evolutionary dynamics and comparative pathogenicity of clade 2.3.4.4b H5 subtype avian influenza viruses, China, 2021~2022 12 hours ago
- Oxymatrine Modulation of TLR3 Signaling: A Dual-Action Mechanism for H9N2 Avian Influenza Virus Defense and Immune Regulation 23 hours ago
- Advax-SM?-Adjuvanted COBRA (H1/H3) Hemagglutinin Influenza Vaccines 23 hours ago
- Triggering Degradation of Host Cellular Proteins for Robust Propagation of Influenza Viruses 23 hours ago
[Go Top] [Close Window]