ROUSSY JF, Abed Y, Bouhy X, Boivin G, et al. Emergence of an oseltamivir-resistant influenza A/H3N2 virus in an elderly receiving a suboptimal dose of antiviral prophylaxis.. J Clin Microbiol. 2013 Oct 2
We report on the emergence of an influenza A/H3N2-E119V neuraminidase variant from an elderly with renal dysfunction who received a suboptimal dose of oseltamivir prophylaxis. In neuraminidase inhibition assays, the E119V variant showed a 413-fold increase in oseltamivir IC50 value and grew at comparable titers than the wild-type in vitro.
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