MIN JY, Santos C, Fitch A, Twaddle A, et al. Mammalian adaptation in the PB2 gene of avian H5N1 influenza virus. J Virol. 2013 Jul 17.
The substitution of glutamic acid (E) for lysine (K) at position 627 of the PB2 protein of avian H5N1 viruses has been identified as a virulence and host-range determinant for infection of mammals. Here, we demonstrate that the E to K host-adaptive mutation in the PB2 gene appeared from day 4 and 5 along the respiratory tract of mice and was complete by day 6 post-inoculation. This mutation correlated with efficient replication of the virus in mice.
See Also:
Latest articles in those days:
- The evolution, complexity, and diversity of swine influenza viruses in China: A hidden public health threat 1 days ago
- MHC class II proteins mediate sialic acid independent entry of human and avian H2N2 influenza A viruses 1 days ago
- Histopathologic Features and Viral Antigen Distribution of H5N1 Highly Pathogenic Avian Influenza Virus Clade 2.3.4.4b from the 2022–2023 Outbreak in Iowa Wild Birds 1 days ago
- Detection and characterization of H5N1 HPAIV in environmental samples from a dairy farm 1 days ago
- Genomic Characterization of Highly Pathogenic Avian Influenza A H5N1 Virus Newly Emerged in Dairy Cattle 1 days ago
[Go Top] [Close Window]