TE VELTHUIS AJ, Turrell L, Vreede FT, Fodor E, et. Uncoupling of influenza A virus transcription and replication through mutation of the unpaired adenosine in the vRNA promoter. J Virol. 2013 Jul 17.
Transcription and replication of the influenza A virus RNA genome are mediated by the viral RNA polymerase from a promoter consisting of the partially base-paired 3´ and 5´ termini of viral genome segments. Here we show that transcription and replication can be uncoupled by mutation of an unpaired adenosine in the 5´-strand of the promoter. This residue is important for transcription but not replication by being essential for the cap-binding activity of the RNA polymerase.
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