Manoj Gambhir,etc.,al. Multiple Contributory Factors to the Age Distribution of Disease Cases: A Modeling Study in the Context of Influenza A(H3N2v). Clin Infect Dis. (2013) 57 (suppl 1): S23-S27 doi
Background. In late 2011 and early 2012, 13 cases of human influenza resulted from infection with a novel triple reassortant swine-origin influenza virus, influenza A (H3N2) variant. This variant was notable for its inclusion of the matrix gene from the 2009 influenza A(H1N1) pandemic virus. While most of these confirmed cases were among children, the transmission potential and likely age-dependent susceptibility to the virus was unknown. Preliminary serologic studies indicated that very young children have less protection than older children and adults.
Methods. We construct a mathematical transmission model of influenza transmission that allows for external zoonotic exposure to infection and show how exposure and susceptibility-related factors contribute to the observed case distribution.
Results and Conclusions. Age-dependent susceptibility to infection strongly influences epidemic dynamics. The result is that the risk of an outbreak in a highly susceptible age group may be substantially higher than in an older age group with less susceptibility, but exposure-related factors must also be accounted for when interpreting case data.
See Also:
Latest articles in those days:
- [preprint] Potential Pathways of Spread of Highly Pathogenic Avian Influenza A/H5N1 Clade 2.3.4.4b Across Dairy Farms in the United States 18 hours ago
- [preprint] The avian and human influenza A virus receptors sialic acid (SA)-α2,3 and SA-α2,6 are widely expressed in the bovine mammary gland 18 hours ago
- Repeatability and reproducibility of hunter-harvest sampling for avian influenza virus surveillance in Great Britain 19 hours ago
- The RBPome of influenza A virus NP-mRNA reveals a role for TDP-43 in viral replication 19 hours ago
- Novel Genotype of HA Clade 2.3.4.4b H5N8 Subtype High Pathogenicity Avian Influenza Virus Emerged at a Wintering Site of Migratory Birds in Japan, 2021/22 Winter 19 hours ago
[Go Top] [Close Window]