Martinez-Romero C, de Vries E, Belicha-Villanueva. Substitutions T200A and E227A in the hemagglutinin of pandemic 2009 influenza A virus increase lethality but decrease transmission. J Virol 2013
We describe that swine influenza virus-like substitutions T200A and E227A in the hemagglutinin of the 2009 pandemic influenza virus alter its pathogenesis and transmission. Viral replication is increased in mammalian cells. Infected mice show increased disease as measured by weight loss and lethality. Transmission in ferrets is decreased in the presence of both substitutions, suggesting that 200T and 227E HA amino acids are adaptive changes in the HA of swine-origin influenza viruses associated with increased transmission and decreased pathogenesis.
See Also:
Latest articles in those days:
- Development and evaluation of a multiplex real-time RT-PCR assay for simultaneous detection of H5, H7, and H9 subtype avian influenza viruses 12 hours ago
- Evolutionary dynamics and comparative pathogenicity of clade 2.3.4.4b H5 subtype avian influenza viruses, China, 2021~2022 12 hours ago
- Oxymatrine Modulation of TLR3 Signaling: A Dual-Action Mechanism for H9N2 Avian Influenza Virus Defense and Immune Regulation 23 hours ago
- Advax-SM?-Adjuvanted COBRA (H1/H3) Hemagglutinin Influenza Vaccines 23 hours ago
- Triggering Degradation of Host Cellular Proteins for Robust Propagation of Influenza Viruses 23 hours ago
[Go Top] [Close Window]