Hoffmann TW, Munier S, Larcher T, Soubieux D, Lede. Length variations in the NA stalk of an H7N1 influenza virus have opposite effects on viral excretion in chickens and ducks. J Virol. 2011 Oct 19
A deletion of ~20 amino acids in the stalk of the neuraminidase is frequently observed upon transmission of influenza A viruses from waterfowl to domestic poultry. A pair of recombinant H7N1 viruses bearing either a short- or long-stalk neuraminidase was genetically engineered. Inoculation of the long-stalk neuraminidase virus resulted in a higher cloacal excretion in ducks and led conversely to a lower oro-pharyngeal excretion in chickens, associated with a higher local immune response and a better survival. Therefore, a short-stalk neuraminidase is a determinant of viral adaptation and virulence in chickens, but is detrimental to virus replication and shedding in ducks.
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