Dennis J. Faix, etc.,al. Rapid-Test Sensitivity for Novel Swine-Origin Influenza A (H1N1) Virus in Humans. N Engl J Med 2009 (published online Jun 29)
From April 20 through May 30, 2009, the center processed 3066 specimens with the use of a real-time reverse-transcriptase–PCR (RT-PCR) assay,2 which revealed 273 confirmed cases of S-OIV (8.9%), 18 cases of H1N1 seasonal influenza (0.6%), and 31 cases of H3N2 influenza (1.0%) (Figure 1). All suspected cases of S-OIV were confirmed with the use of the CDC´s S-OIV assay.2 All specimens were collected from patients with influenza-like illness who met the CDC´s guidelines for screening. Rapid-test results for 767 patients during this influenza season were available for comparison and were positive for 20 of 39 patients who had positive results for S-OIV on RT-PCR assay (sensitivity, 51%; 95% confidence interval [CI], 35 to 67), for 12 of 19 patients who had positive results for H1N1 seasonal influenza on RT-PCR (sensitivity, 63%; 95% CI, 39 to 82), and for 6 of 19 of patients who had positive results for H3N2 influenza on RT-PCR (sensitivity, 31%; 95% CI, 14 to 57). The specificity of the test, as compared with that of RT-PCR, was 99% in all cases.
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