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2024-11-22 22:00:53


Wu G, Yan S. Fate of 130 hemagglutinins from different influenza A viruses. Biochem Biophys Res Commun. 2004 May 7;317(3):917-24
submited by DreamSciTech at Nov, 29, 2006 7:5 AM from Biochem Biophys Res Commun. 2004 May 7;317(3):917-24

In this study, we use our probabilistic models to analyze 130 hemagglutinins from different influenza A virus in order to gain the insight into their fate. The results provide three lines of evidence regarding the H5, H6, and H9 hemagglutinins: (i) the H5 hemagglutinins are more sensitive to mutations, this is the current state of the H5, H6, and H9 hemagglutinins; (ii) the H5 hemagglutinins had experienced more mutations in the past, this is the history of the H5, H6, and H9 hemagglutinins; and (iii) the H6 hemagglutinins has a bigger potential towards future mutations, this is the future of the H5, H6, and H9 hemagglutinins. Furthermore, this study gives two clues on the mutation tendency that is a degeneration process and the species susceptibility that is the chickens and ducks.

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