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2020-4-7 0:35:20


White MR, Crouch E, Vesona J, Tacken PJ, Batenburg JJ, Leth-Larsen R, Holmskov U, Hartshorn KL. Respiratory Innate Immune Proteins Differentially Modulate the Neutrophil Respiratory Burst Response to Influenza A Virus. Am J Physiol Lung Cell Mol Physiol. 2005 Jun 10; [Epub ahead of print]
submited by kickingbird at Jun, 17, 2005 9:15 AM from Am J Physiol Lung Cell Mol Physiol. 2005 Jun 10; [Epub ahead of print]

Respiratory Innate Immune Proteins Differentially Modulate the Neutrophil Respiratory Burst Response to Influenza A Virus.

White MR, Crouch E, Vesona J, Tacken PJ, Batenburg JJ, Leth-Larsen R, Holmskov U, Hartshorn KL.


Department of Medicine, Boston University School of Medicine, Boston, MA, USA.

Oxidants and neutrophils contribute to lung injury during influenza A virus (IAV) infection. Surfactant protein D plays a pivotal role in restricting IAV replication and inflammation in the first several days after infection. Despite its potent anti-inflammatory effects in vivo, pre-incubation of IAV with SP-D in vitro strongly increases neutrophil respiratory burst responses to the virus. Several factors are shown to modify this apparent pro-inflammatory effect of SP-D. Although multimeric forms of SP-D show dose-dependent augmentation of respiratory burst responses, trimeric, single-arm forms show either no effect or inhibit these responses. Furthermore, if neutrophils are pre-incubated with multimeric SP-D before adding IAV, oxidant responses to the virus are significantly reduced. The ability of SP-D to increase neutrophil uptake of IAV can be dissociated from enhancement of oxidant responses. Finally, several other innate immune proteins that bind to SP-D and/or IAV (i.e. SP-A, lung gp-340 or mucin) significantly reduce the ability of SP-D to promote neutrophil oxidant response. As a result, the net effect of bronchoalveolar lavage (BAL) fluids is to increase neutrophil uptake of IAV while reducing the respiratory burst response to virus.

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