Vreede FT, Jung TE, Brownlee GG. Model suggesting that replication of influenza virus is regulated by stabilization of replicative intermediates. J Virol. 2004 Sep;78(17):9568-72
Model suggesting that replication of influenza virus is regulated by stabilization of replicative intermediates.
Vreede FT, Jung TE, Brownlee GG.
Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom.
The RNA-dependent RNA polymerase of influenza A virus is responsible for both transcription and replication of negative-sense viral RNA. It is thought that a "switching" mechanism regulates the transition between these activities. We demonstrate that, in the presence of preexisting viral RNA polymerase and nucleoprotein (NP), influenza A virus synthesizes both mRNA (transcription) and cRNA (replication) early in infection. We suggest that there may be no switch regulating the initiation of RNA synthesis and present a model suggesting that nascent cRNA is degraded by host cell nucleases unless it is stabilized by newly synthesized viral RNA polymerase and NP.
Vreede FT, Jung TE, Brownlee GG.
Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom.
The RNA-dependent RNA polymerase of influenza A virus is responsible for both transcription and replication of negative-sense viral RNA. It is thought that a "switching" mechanism regulates the transition between these activities. We demonstrate that, in the presence of preexisting viral RNA polymerase and nucleoprotein (NP), influenza A virus synthesizes both mRNA (transcription) and cRNA (replication) early in infection. We suggest that there may be no switch regulating the initiation of RNA synthesis and present a model suggesting that nascent cRNA is degraded by host cell nucleases unless it is stabilized by newly synthesized viral RNA polymerase and NP.
See Also:
Latest articles in those days:
- A dominant internal gene cassette of high pathogenicity avian influenza H7N9 virus raised since 2018 2 days ago
- A Eurasian avian-like H1N1 swine influenza reassortant virus became pathogenic and highly transmissible due to mutations in its PA gene 3 days ago
- Few Amino Acid Mutations in H6 Influenza A Virus From South American Lineage Increase Viral Replication Efficiency in Poultry 3 days ago
- Monoclonal antibodies targeting the influenza virus N6 neuraminidase 3 days ago
- Vital sign predictors of severe influenza among children in an emergent care setting 5 days ago
[Go Top] [Close Window]