Yang Y, Liu H, Li Y, Liu L, Chen T, Zhang J. Emergence of a novel H4N6 avian influenza virus with mammalian adaptation isolated from migratory birds in Zhejiang Province, China, 2024. Virol Sin. 2026 Mar 13:S1995-820X(26)00042-8
HIGHLIGHTS:
The H4N6/G030 strain, a novel H4N6 avian influenza virus (AIV), was isolated from a red-necked stint.
The H4N6/G030 is a novel cross-species reassortant derived from wild bird and poultry AIV lineages.
The H4N6/G030 can bind to both avian and mammalian-type sialic acid receptors, and replicate in both avian and mammalian cells and cause disease in animals.
High seroprevalence of H4N6 was observed on surveyed poultry farms nearby.
The H4N6/G030 strain, a novel H4N6 avian influenza virus (AIV), was isolated from a red-necked stint.
The H4N6/G030 is a novel cross-species reassortant derived from wild bird and poultry AIV lineages.
The H4N6/G030 can bind to both avian and mammalian-type sialic acid receptors, and replicate in both avian and mammalian cells and cause disease in animals.
High seroprevalence of H4N6 was observed on surveyed poultry farms nearby.
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