Avian influenza subtype A(HxNy) normally spreads in birds but can also infect humans. Human infections are primarily acquired through direct contact with infected poultry or contaminated environments. While avian influenza viruses do not currently transmit easily from person to person, the ongoing circulation of these viruses in poultry is concerning, as these viruses can result in mild to severe illness and death, and also have the potential to mutate to become more contagious.

This weekly situation report will highlight the most recent developments in the regional response.

From 11 to 17 July 2025, one new case of human infection with avian influenza A(H5N1) virus wasreported to WHO in the Western Pacific Region. The case was from Kampot Province, Cambodia with onset of symptoms on 24 June. The case was known to have exposure to sick or dead poultry and passed away on 16 July 2025.
From 1 January 2003 to 1 July 2025, a total of 474 cases of human infection with avian influenza A(H5N1) virus have been reported from six countries within the Western Pacific Region. Of these cases, 316 were fatal, resulting in a case fatality rate (CFR) of 66.7%.

From 11 to 17 July 2025, two new cases of human infection with avian influenza A(H9N2) virus were reported to WHO in the Western Pacific Region. The first case was from Guangdong Province with onset of symptoms on 28 May 2025 and the second case was from Hubei Province with onset of symptoms on 21 June 2025. Both cases have recovered without hospitalization. They were known to have exposure to poultry.
Since December 2015, a total of 135 cases of human infection with avian influenza A(H9N2), including two deaths (both with underlying conditions), have been reported to WHO in the Western Pacific Region. Of these, 132 were reported from China, two were reported from Cambodia, and one was reported from Viet Nam.