Denz PJ, Speaks S, Kenney AD, Eddy AC, Papa JL, Ro. Innate immune control of influenza virus interspecies adaptation via IFITM3. Nat Commun. 2024 Oct 30;15(1):9375
Influenza virus pandemics are caused by viruses from animal reservoirs that adapt to efficiently infect and replicate in human hosts. Here, we investigate whether Interferon-Induced Transmembrane Protein 3 (IFITM3), a host antiviral factor with known human deficiencies, plays a role in interspecies virus infection and adaptation. We find that IFITM3-deficient mice and human cells can be infected with low doses of avian influenza viruses that fail to infect WT counterparts, identifying a new role for IFITM3 in controlling the minimum infectious virus dose threshold. Remarkably, influenza viruses passaged through Ifitm3-/- mice exhibit enhanced host adaptation, a result that is distinct from viruses passaged in mice deficient for interferon signaling, which exhibit attenuation. Our data demonstrate that IFITM3 deficiency uniquely facilitates potentially zoonotic influenza virus infections and subsequent adaptation, implicating IFITM3 deficiencies in the human population as a vulnerability for emergence of new pandemic viruses.
See Also:
Latest articles in those days:
- Comprehensive Molecular Epidemiology of Influenza Viruses in Brazil: Insights from a Nationwide Analysis 1 days ago
- Pandemic preparedness of effective vaccines for the outbreak of newly H5N1 highly pathogenic avian influenza virus 1 days ago
- The PB1 protein of H9N2 influenza A virus inhibits antiviral innate immunity by targeting MAVS for TRIM25-mediated autophagic degradation 1 days ago
- The evolution of hemagglutinin-158 and neuraminidase-88 glycosylation sites modulates antigenicity and pathogenicity of clade 2.3.2.1 H5N1 avian influenza viruses 1 days ago
- Evidence of Influenza A(H5N1) Spillover Infections in Horses, Mongolia 1 days ago
[Go Top] [Close Window]