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2024-6-22 10:30:35

Chua SCJH, Cui J, Sachaphibulkij K, Tan ISL, Tan H. The ER-Golgi transport of influenza virus through NS1-Sec13 association during virus replication. Microbiol Spectr. 2023 Dec 1:e0260923
submited by kickingbird at Dec, 2, 2023 8:50 AM from Microbiol Spectr. 2023 Dec 1:e0260923

Influenza A virus is a respiratory virus that can cause complications such as acute bronchitis and secondary bacterial pneumonia. Drug therapies and vaccines are available against influenza, albeit limited by drug resistance and the non-universal vaccine administration. Hence there is a need for host-targeted therapies against influenza to provide an effective alternative therapeutic target. Sec13 was identified as a novel host interactor of influenza. Endoplasmic reticulum-to-Golgi transport is an important pathway of influenza virus replication and viral export. Specifically, Sec13 has a functional role in influenza replication and virulence.

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