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2022-10-5 1:34:22

Reina J. The new generation of messenger RNA (mRNA) vaccines against influenza. Enferm Infecc Microbiol Clin (Engl Ed). 2022 Jul 2
submited by kickingbird at Jul, 31, 2022 10:47 AM from Enferm Infecc Microbiol Clin (Engl Ed). 2022 Jul 2

Today there are multiple types of flu vaccines. The emergence of nucleic acid technology used in vaccines against SARS-CoV-2 suggests its future application against this infection. Against influenza, two types of vaccines have been developed based on messenger RNA (mRNA): conventional or non-replicative and self-amplifying or replicative (auRNA), both included in lipid nanoparticles. Animal studies carried out with the former have shown their strong capacity to induce Th-1 antibodies and cellular immunity against influenza haemagglutinin (HA) with few side effects. Human trials have shown 87% seroconversion and 100% seroprotection. The auRNA vaccines have obtained similar results in animals but at a concentration 64 times lower than the conventional one. Vaccines based on mRNA platforms meet the WHO requirements for next generation influenza vaccines.

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