Ding L, Chen Y, Su N, Xu X, Yin J, Qiu J, Wang J,. Comparison of acute respiratory distress syndrome in patients with COVID-19 and influenza A (H7N9) virus infection. Int J Infect Dis. 2022 Jul 3:S1201-9712(22)00387-3
Methods: Clinical data of 100 COVID-19 patients and 46 H7N9 patients were retrospectively analyzed.
Results: Elevated inflammatory indices and coagulation disorders were more common in COVID-19-ARDS group than in H7N9-ARDS group. The median interval from illness onset to ARDS development was shorter in H7N9-ARDS. The PaO2/FiO2 level was lower in H7N9-ARDS, while SOFA score was higher in COVID-19-ARDS. The proportion of patients with disseminated intravascular coagulation and liver injury in COVID-19-ARDS and H7N9-ARDS was 45.5% vs 3.1%, and 28.8% vs 50%, respectively (P<0.05). The mean interval from illness onset to death was shorter in H7N9-ARDS. 59.1% patients with H7N9-ARDS died of refractory hypoxemia as against 28.9% with COVID-19-ARDS (P=0.014). Patients with COVID-19-ARDS were more likely to die of septic shock and multiple-organ dysfunction compared to H7N9-ARDS (71.2% vs 36.4%, P=0.005).
Conclusion: H7N9 patients were more susceptible to develop severe ARDS and showed a more acute disease course. COVID-19-ARDS was associated with severe inflammatory response and coagulation dysfunction, while liver injury was more common in H7N9-ARDS. The main causes of death between patients with the two diseases were different.
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