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2022-8-12 4:24:44

Xiong W, Tsang TK, Perera RAPM, Leung NHL, Fang VJ. Biphasic waning of hemagglutination inhibition antibody titers after influenza vaccination in children. J Infect Dis. 2022 Apr 5:jiac117
submited by kickingbird at Apr, 6, 2022 15:23 PM from J Infect Dis. 2022 Apr 5:jiac117

We explored the potential for a biphasic pattern in waning of antibody titers after influenza vaccination. We collected blood samples in a randomized controlled trial of influenza vaccination in children, and tested them with hemagglutination inhibition (HAI) assays for influenza A(H3N2) and influenza B/Victoria lineage. Using piecewise log-linear mixed-effect models, we found evidence for a faster initial waning of antibody titers for the first 1-2 years after vaccination and then slower longer-term declines. Children with higher post-vaccination titers had faster antibody decay.

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