-

nihao guest [ sign in / register ]
2022-8-12 4:13:07


Vinh DN, Nhat NTD, de Bruin E, Vy NHT, Thao TTN, P. Age-seroprevalence curves for the multi-strain structure of influenza A virus. Nat Commun. 2021 Nov 18;12(1):6680
submited by kickingbird at Nov, 21, 2021 10:11 AM from Nat Commun. 2021 Nov 18;12(1):6680

The relationship between age and seroprevalence can be used to estimate the annual attack rate of an infectious disease. For pathogens with multiple serologically distinct strains, there is a need to describe composite exposure to an antigenically variable group of pathogens. In this study, we assay 24,402 general-population serum samples, collected in Vietnam between 2009 to 2015, for antibodies to eleven human influenza A strains. We report that a principal components decomposition of antibody titer data gives the first principal component as an appropriate surrogate for seroprevalence; this results in annual attack rate estimates of 25.6% (95% CI: 24.1% - 27.1%) for subtype H3 and 16.0% (95% CI: 14.7% - 17.3%) for subtype H1. The remaining principal components separate the strains by serological similarity and associate birth cohorts with their particular influenza histories. Our work shows that dimensionality reduction can be used on human antibody profiles to construct an age-seroprevalence relationship for antigenically variable pathogens.

See Also:

Latest articles in those days:

[Go Top]    [Close Window]

Related Pages:
Learn about the flu news, articles, events and more
Subscribe to the weekly F.I.C newsletter!


  

Site map  |   Contact us  |  Term of use  |  FAQs |  粤ICP备10094839号-1
Copyright ©www.flu.org.cn. 2004-2022. All Rights Reserved. Powered by FIC 4.0.1
  Email:webmaster@flu.org.cn