Damjanovska S, Smith C, Sayin I, Burant CJ, Graven. Adjuvant effect of type I interferon induced by many but not all commercial influenza vaccines. Vaccine. 2020 Dec 31:S0264-410X(20)31631-5
Objective: Our aim was to determine if IFN-α induction in peripheral blood mononuclear cells (PBMCs) exposed to eight different commercial influenza vaccines is a pDC-dependent process mediated through TLR-7 signaling.
Results: We demonstrate the ability of multiple vaccines to induce IFN-α in a TLR-7-dependent fashion. A number of vaccines however lacked IFN-α induction. The significance of these differences between vaccines is unclear, since all the approved vaccine formulations offer some degree of protection.
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