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2020-9-20 18:50:28


Vandoorn E, Leroux-Roels I, Leroux-Roels G, Parys. Detection of H1 Swine Influenza A Virus Antibodies in Human Serum Samples by Age Group. Emerg Infect Dis. 2020;26(9):2118-2128
submited by kickingbird at Aug, 25, 2020 11:16 AM from Emerg Infect Dis. 2020;26(9):2118-2128

Most H1 influenza A viruses (IAVs) of swine are derived from past human viruses. As human population immunity against these IAVs gradually decreases, the risk of reintroduction to humans increases. We examined 549 serum samples from persons 0-97 years of age collected in Belgium during 2017-2018 for hemagglutination inhibiting and virus neutralizing antibodies against 7 major H1 swine IAV (swIAV) clades and 3 human progenitor IAVs. Seroprevalence (titers >40) rates were >50% for classical swine and European human-like swIAVs, >24% for North American human-like δ1a and Asian avian-like swIAVs, and <10% for North American human-like δ1b and European avian-like swIAVs, but rates were age-dependent. Antibody titers against human-like swIAVs and supposed human precursor IAVs correlated with correlation coefficients of 0.30-0.86. Our serologic findings suggest that European avian-like, clade 1C.2.1, and North American human-like δ1b, clade 1B.2.2.2, H1 swIAVs pose the highest pandemic risk.

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