Wu NC, Thompson AJ, Lee JM, et al. Different Genetic Barriers for Resistance to HA Stem Antibodies in Influenza H3 and H1 Viruses. Science. 2020;368(6497):1335-1340
The discovery and characterization of broadly neutralizing human antibodies (bnAbs) to the highly conserved stem region of influenza hemagglutinin (HA) have contributed to considerations of a universal influenza vaccine. However, the potential for resistance to stem bnAbs also needs to be more thoroughly evaluated. Using deep mutational scanning, with a focus on epitope residues, we found that the genetic barrier to resistance to stem bnAbs is low for the H3 subtype but substantially higher for the H1 subtype owing to structural differences in the HA stem. Several strong resistance mutations in H3 can be observed in naturally circulating strains and do not reduce in vitro viral fitness and in vivo pathogenicity. This study highlights a potential challenge for development of a truly universal influenza vaccine.
See Also:
Latest articles in those days:
- Phylogeography and gene pool analysis of highly pathogenic avian influenza H5N1 viruses reported in India from 2006 to 2021 23 hours ago
- Analysis of a diffusive epidemic model with a zero-infection zone 1 days ago
- Quick detection of H5N1 avian influenza virus by surface enhanced Raman scattering(SERS) using aptamer capture 1 days ago
- The critical role of RAGE in severe influenza infection: A target for control of inflammatory response in the disease 1 days ago
- Human infection caused by avian influenza A (H10N5) virus 1 days ago
[Go Top] [Close Window]