Wangchareansak T, et al. Influenza A virus molecularly imprinted polymers and their application in virus sub-type classification. J Mater Chem B. 2013 Apr 28;1(16):2190-2197
In this work, we apply a molecular imprinting strategy as a screening protocol for different influenza A subtypes, namely H5N1, H5N3, H1N1, H1N3 and H6N1. Molecularly imprinted polymers for each of these subtypes lead to appreciable sensor characteristics on a quartz crystal microbalance leading to detection limits as low as 105 particles per ml. Selectivity studies indicate that each virus is preferably incorporated by its own MIP. Recognition in most cases is dominated by the neuraminidase residue rather than the hemagglutinin. Multivariate analysis shows that the sensor responses can be correlated with the differences in hemagglutinin and neuraminidase patterns from databases. This allows for virus subtype characterization and thus rapid screening.
See Also:
Latest articles in those days:
- Host Species Contribution to the Spatiotemporal Dynamics of the 2024-2025 H5N1 Epidemic in Italy 14 hours ago
- mRNA-based influenza vaccine expands the B cell response breadth in humans 14 hours ago
- Molecular surveillance and predictive risk modelling of avian influenza virus in wild birds in Egypt 14 hours ago
- Germany as a key transit hub for the emergence and spread of high pathogenicity avian influenza H5 clade 2.3.4.4b reassortants in Europe 2 days ago
- Degradation of ACSL3 by influenza A virus shifts unfolded protein response from antiviral defense to viral evasion 2 days ago
[Go Top] [Close Window]


