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2020-7-14 15:16:33

Evseenko VA, et al. Comparative thermostability analysis of zoonotic and human influenza virus A and B neuraminidase. Arch Virol. 2019 Nov 19.
submited by kickingbird at Nov, 25, 2019 9:11 AM from Arch Virol. 2019 Nov 19.

Neuraminidase (NA) thermostability of influenza A and B viruses isolated from birds, swine and humans was measured to evaluate its variability associated with host body temperature. The highest 50% inactivation temperature (IT50) was observed with H3N8 avian influenza virus (74 °C), and the lowest IT50 was observed with the seasonal human H3N2 virus (45.5 °C). The IT50 values of A(H1N1)pdm09 viruses 56.4-58.5 °C were statistically higher than that of the prepandemic strain A/Solomon Islands/03/06 (52.5 °C). An analysis of Ca2+ binding sites revealed the correspondence of amino acid changes to NA thermostability. This study demonstrates that changes in NA thermostability correspond to differences in host body temperature.

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