Tang BM, Feng CG, McLean AS. Understanding the role of host response in influenza pneumonitis. Intensive Care Med. 2019 Apr 24.
Most influenza-related deaths are caused by influenza pneumonitis, a serious complication of influenza virus infection characterised by uncontrolled lung inflammation, acute lung injury and respiratory failure. This serious complication has a high mortality risk (18–32%) [1]. The currently available antiviral therapy (e.g. neuraminidase inhibitor) has limited efficacy in reducing fatality caused by influenza pneumonitis.
Host factors, in additional to viral factors, are important in determining patient outcomes in influenza pneumonitis [2, 3]. A better understanding of the host factors associated with severe disease is therefore needed; it may help discover pathogenic pathways that determine disease progression and enable researchers identify new therapeutic targets. Here, we examine the immune cells underpinning the host response to influenza infection.
Host factors, in additional to viral factors, are important in determining patient outcomes in influenza pneumonitis [2, 3]. A better understanding of the host factors associated with severe disease is therefore needed; it may help discover pathogenic pathways that determine disease progression and enable researchers identify new therapeutic targets. Here, we examine the immune cells underpinning the host response to influenza infection.
See Also:
Latest articles in those days:
- In turkeys, unlike chickens, the non-structural NS1 protein does not play a significant role in the replication and tissue tropism of the H7N1 avian influenza virus 4 hours ago
- The evolution, complexity, and diversity of swine influenza viruses in China: A hidden public health threat 2 days ago
- MHC class II proteins mediate sialic acid independent entry of human and avian H2N2 influenza A viruses 2 days ago
- Histopathologic Features and Viral Antigen Distribution of H5N1 Highly Pathogenic Avian Influenza Virus Clade 2.3.4.4b from the 2022–2023 Outbreak in Iowa Wild Birds 2 days ago
- Detection and characterization of H5N1 HPAIV in environmental samples from a dairy farm 2 days ago
[Go Top] [Close Window]