Yu J, etc.,al. Influenza-Associated Hospitalization in Children Younger Than Five Years of Age in Suzhou, China, 2011- 2016. Pediatr Infect Dis J. 2018 Aug 27.
BACKGROUND:
Studying the burden and risk factors associated with severe illness from influenza infection in young children in eastern China will contribute to future cost-effectiveness analyses of local influenza vaccine programs.
METHODS:
We conducted prospective, severe acute respiratory infection (SARI) surveillance at Suzhou University Affiliated Children´s Hospital (SCH) to estimate influenza-associated hospitalizations in SCH by month in children younger than 5 years of age from October 2011 to September 2016. SARI was defined as fever (measured axillary temperature ≥38°C) and cough or sore throat or inflamed/red pharynx in the 7 days preceding hospitalization. We combined SARI surveillance data with healthcare utilization survey data to estimate and characterize the burden of influenza-associated SARI hospitalizations in Suzhou within this age group in the 5-year period.
RESULTS:
Of 36,313 SARI cases identified, 2,297 from respiratory wards were systematically sampled; of these, 259 (11%) were influenza positive. Estimated annual influenza-associated SARI hospitalization rates per 1,000 children younger than 5 years of age ranged from 4 (95% Confidence Interval [CI]: 2-5) in the 2012-2013 season to 16 (95% CI: 14-19) in the 2011-2012 season. The predominant viruses were A/H3N2 (59%) in 2011-12, both A/H1N1pdm09 (42%) and B (46%) in 2012-13, A/H3N2 (71%) in 2013-14, A/H3N2 (55%) in 2014-15 and both A/H1N1pdm09 (50%) and B (50%) in 2015-16. The age-specific influenza-associated SARI hospitalization rates for the 5-year period were 11 (95% CI: 8-15) per 1,000 children aged 0-5 months; 8 (95% CI: 7-10) per 1,000 children aged 6-23 months; and 5 (95% CI: 4-5) per 1,000 children aged 24-59 months respectively.
CONCLUSIONS:
From 2011-2016, influenza-associated SARI hospitalization rates in children aged younger than 5 years of age in Suzhou, China were high, particularly among children aged 0-5 months. Higher hospitalization rates were observed in years where the predominant circulating virus was influenza A/H3N2. Immunization for children >6 months, and maternal and caregiver immunization for those <6 months, could reduce influenza-associated hospitalizations in young children in Suzhou.
Studying the burden and risk factors associated with severe illness from influenza infection in young children in eastern China will contribute to future cost-effectiveness analyses of local influenza vaccine programs.
METHODS:
We conducted prospective, severe acute respiratory infection (SARI) surveillance at Suzhou University Affiliated Children´s Hospital (SCH) to estimate influenza-associated hospitalizations in SCH by month in children younger than 5 years of age from October 2011 to September 2016. SARI was defined as fever (measured axillary temperature ≥38°C) and cough or sore throat or inflamed/red pharynx in the 7 days preceding hospitalization. We combined SARI surveillance data with healthcare utilization survey data to estimate and characterize the burden of influenza-associated SARI hospitalizations in Suzhou within this age group in the 5-year period.
RESULTS:
Of 36,313 SARI cases identified, 2,297 from respiratory wards were systematically sampled; of these, 259 (11%) were influenza positive. Estimated annual influenza-associated SARI hospitalization rates per 1,000 children younger than 5 years of age ranged from 4 (95% Confidence Interval [CI]: 2-5) in the 2012-2013 season to 16 (95% CI: 14-19) in the 2011-2012 season. The predominant viruses were A/H3N2 (59%) in 2011-12, both A/H1N1pdm09 (42%) and B (46%) in 2012-13, A/H3N2 (71%) in 2013-14, A/H3N2 (55%) in 2014-15 and both A/H1N1pdm09 (50%) and B (50%) in 2015-16. The age-specific influenza-associated SARI hospitalization rates for the 5-year period were 11 (95% CI: 8-15) per 1,000 children aged 0-5 months; 8 (95% CI: 7-10) per 1,000 children aged 6-23 months; and 5 (95% CI: 4-5) per 1,000 children aged 24-59 months respectively.
CONCLUSIONS:
From 2011-2016, influenza-associated SARI hospitalization rates in children aged younger than 5 years of age in Suzhou, China were high, particularly among children aged 0-5 months. Higher hospitalization rates were observed in years where the predominant circulating virus was influenza A/H3N2. Immunization for children >6 months, and maternal and caregiver immunization for those <6 months, could reduce influenza-associated hospitalizations in young children in Suzhou.
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