Wang J, etc.,al. A study on mother-to-fetus/infant transmission of influenza A(H7N9) virus: two case reports and a review of literature. Clin Respir J. 2018 Aug 20
OBJECTIVES:
The prevention strategies for mother-to-fetus/infant transmission of H7N9 virus have not been well understood, and the study on this subject will provide further insights.
METHODS:
Reverse transcriptase polymerase chain reaction assay was undertaken to detect H7N9 virus in samples from a pregnant women, a postpartum woman, and their fetus/infant. Pathological features of tissues from the dead fetus were evaluated with hematoxylin and eosin staining. Hemagglutination inhibition assay was used to detect virus-specific antibodies. Furthermore, relevant literatures were reviewed and analyzed.
RESULTS:
A 28-year-old pregnant woman was hospitalized for H7N9 infection and prescribed with oseltamivir and peramivir two days before admission. The fetal heart beating stopped on day four, the dead fetus was delivered on day 13, and the woman expired on day 26. All fetal tissues were H7N9 virus-negative. A 28-year-old woman delivered a newborn on December 20, 2016. Five days later she developed influenza-like symptoms and was confirmed with H7N9 infection. She had close contact with her infant for nine days. Oseltamivir and peramivir were prescribed within two days after illness onset. A throat swab and a pair of serum samples from the infant were all negative for H7N9 virus during four-week follow-up. In total, ten studies referring to transplacental transmission and four reports on maternal infection of H7N9 virus were reviewed and analyzed.
CONCLUSION:
No evidence showed H7N9 virus infection in both fetus and infant. The early administration of neuraminidase inhibitor seemed beneficial in preventing mother-to-fetus/infant transmission of H7N9 virus.
The prevention strategies for mother-to-fetus/infant transmission of H7N9 virus have not been well understood, and the study on this subject will provide further insights.
METHODS:
Reverse transcriptase polymerase chain reaction assay was undertaken to detect H7N9 virus in samples from a pregnant women, a postpartum woman, and their fetus/infant. Pathological features of tissues from the dead fetus were evaluated with hematoxylin and eosin staining. Hemagglutination inhibition assay was used to detect virus-specific antibodies. Furthermore, relevant literatures were reviewed and analyzed.
RESULTS:
A 28-year-old pregnant woman was hospitalized for H7N9 infection and prescribed with oseltamivir and peramivir two days before admission. The fetal heart beating stopped on day four, the dead fetus was delivered on day 13, and the woman expired on day 26. All fetal tissues were H7N9 virus-negative. A 28-year-old woman delivered a newborn on December 20, 2016. Five days later she developed influenza-like symptoms and was confirmed with H7N9 infection. She had close contact with her infant for nine days. Oseltamivir and peramivir were prescribed within two days after illness onset. A throat swab and a pair of serum samples from the infant were all negative for H7N9 virus during four-week follow-up. In total, ten studies referring to transplacental transmission and four reports on maternal infection of H7N9 virus were reviewed and analyzed.
CONCLUSION:
No evidence showed H7N9 virus infection in both fetus and infant. The early administration of neuraminidase inhibitor seemed beneficial in preventing mother-to-fetus/infant transmission of H7N9 virus.
See Also:
Latest articles in those days:
- Latest developments in early diagnosis and specific treatment of severe influenza infection 3 hours ago
- Factors affecting highly pathogenic avian influenza vaccination practices at poultry farms in Tra Vinh, Vietnam 3 hours ago
- Establishment of Swine Primary Nasal, Tracheal, and Bronchial Epithelial Cell Culture Models for the Study of Influenza Virus Infection 1 days ago
- Highly pathogenic avian influenza H5N1 virus infections in pinnipeds and seabirds in Uruguay: implications for bird-mammal transmission in South America 1 days ago
- Development and evaluation of a multiplex real-time RT-PCR assay for simultaneous detection of H5, H7, and H9 subtype avian influenza viruses 2 days ago
[Go Top] [Close Window]