POHL MO, Lanz C, Stertz S. Late stages of the influenza A virus replication cycle - a tight interplay between virus and host.. J Gen Virol. 2016 Jul 22.
After successful infection and replication of its genome in the nucleus of the host cell influenza A virus faces several challenges before newly assembled viral particles can bud off from the plasma membrane, giving rise to new infectious virus. The vRNP complexes need to exit from the nucleus and be transported to the virus assembly sites at the plasma membrane. Moreover, they need to be bundled to ensure the incorporation of precisely one of each of the eight viral genome segments into newly formed viral particles. Similarly, viral envelope glycoproteins and other viral structural proteins need to be targeted to virus assembly sites for viral particles to form and bud off from the plasma membrane. During all these steps influenza A virus heavily relies on a tight interplay with its host, exploiting host cell proteins for its own purposes. In this review we summarize current knowledge on late stages of the influenza virus replication cycle, focusing on the role of host cell proteins involved in this process
See Also:
Latest articles in those days:
- [preprint] Emergence and interstate spread of highly pathogenic avian influenza A(H5N1) in dairy cattle 12 hours ago
- Modelling the transmission dynamics of H9N2 avian influenza viruses in a live bird market 12 hours ago
- CD8+ T-cell responses towards conserved influenza B virus epitopes across anatomical sites and age 3 days ago
- Surveillance for highly pathogenic avian influenza A (H5N1) in a raptor rehabilitation center-2022 3 days ago
- [preprint]Detection of hemagglutinin H5 influenza A virus sequence in municipal wastewater solids at wastewater treatment plants with increases in influenza A in spring, 2024 3 days ago
[Go Top] [Close Window]