Ongoing transmission of avian influenza A viruses in Hong Kong despite very comprehensive poultry control measures: a prospective seroepidemiology study

TO KK, Hung IF, Lui YM, Mok FK, et al. Ongoing transmission of avian influenza A viruses in Hong Kong despite very comprehensive poultry control measures: a prospective seroepidemiology study. J Infect. 2015 Nov 26.
submited by kickingbird at Dec, 7, 2015 8:30 AM from J Infect. 2015 Nov 26.

OBJECTIVES:

Stringent measures have been implemented in Hong Kong to prevent human infections due to avian influenza viruses (AIVs). Here, we report the seroprevalence of AIVs among high risk population.

METHODS:

In this prospective study, blood samples were collected in October and November 2013 and in July 2014 from workers at live poultry market (LPM) and pig/cattle slaughterhouse (SH) in Hong Kong. Serum antibody titers against A(H5N1), A(H7N9) and A(H9N2) were determined.

RESULTS:

When an hemagglutination inhibition (HI) titer of 40 was used as the cutoff, the A(H5N1) seropositive rate among LPM workers increased from 0% in 2013 to 37.8% in 2014 (P<0.001) and the A(H9N2) seropositive rate increased from 10% to 55.6% (P<0.001). There was no significant increase in A(H7N9) seropositive rate for LPM workers irrespective of cutoff titer. For SH workers, there was no significant increase in HI titer for any AIVs. Significantly more LPM workers had a ≥4-fold increase in A(H5N1) HI titer from 2013 to 2014 than SH workers (60% vs 8.3%, P=0.020).

CONCLUSIONS:

There was a significant increase of serum A(H5N1) and A(H9N2) HI titers among Hong Kong LPM workers between 2013 and 2014, suggesting the occurrence of subclinical AIV infections in this population.