From 19 December to 8 January 2026, three new cases of human infection with avian influenza A(H9N2) virus were reported to WHO in the Western Pacific Region. On 12 December 2025, the National Health Commission of the People´s Republic of China notified WHO of three laboratory-confirmed human infections with avian influenza A(H9N2) virus diagnosed in November 2025. The first case is a 10-year-old male from Guangxi Province, with exposure to backyard poultry, who developed symptoms on 2 November 2025. The second case is a 73-year-old male from Hubei Province, with exposure to live poultry market, who developed symptoms on 1 November 2025. The third case is a 71-year-old male from Guangdong Province, with no history of direct contact with live poultry, who developed symptoms on 9 November 2025. Two of the cases required hospitalization. Since December 2015, a total of 152 cases of human infection with avian influenza A(H9N2), including two deaths (both with underlying conditions), have been reported to WHO in the Western Pacific Region. Of these, 149 were reported from China, two were from Cambodia, and one was from Viet Nam.