DES MOINES, Iowa (Feb. 2, 2025) - The Iowa Department of Agriculture and Land Stewardship and the United States Department of Agriculture (USDA) Animal and Plant Health Inspection Service (APHIS) have detected a case of Highly Pathogenic Avian Influenza (H5N1 HPAI) in a commercial layer flock in O’Brien County, Iowa. This is Iowa’s second detection of H5N1 HPAI within domestic birds in 2025.