Following an investigation by the Michigan Department of Agriculture and Rural Development (MDARD), the Michigan State University Veterinary Diagnostic Laboratory has detected the presence of highly pathogenic avian influenza (HPAI) in a backyard flock from Oakland County. This is the second case of HPAI in Oakland County since the virus was first detected in Michigan in 2022. Adhering to biosecurity measures and using personal protective equipment (PPE) continue to be vital in helping ensure the health of Michigan´s domestic animals and the general public.