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Jang Y, Jin M, Seo SH. Histamine contributes to severe pneumonia in pigs infected with 2009 pandemic H1N1 influenza virus. Arch Virol. 2018 Jul 31..  Abstract  
submitted by kickingbird at Aug, 5, 2018 from Arch Virol. 2018 Jul 31. (via https://www.ncbi.nlm.nih.gov/pubmed/30066270)
Histamine is a biogenic amine that influences many immune cells. In this study, we investigated the effect of histamine on the pathogenesis of 2009 pandemic H1N1 influenza virus in pigs. Histamine was ...

Al Khatib HA, Al Thani AA, Yassine HM. Evolution and dynamics of the pandemic H1N1 influenza hemagglutinin protein from 2009 to 2017. Arch Virol. 2018 Jul 31. doi: 10.1007/s00705-018-3.  Abstract  
submitted by kickingbird at Aug, 5, 2018 from Arch Virol. 2018 Jul 31. doi: 10.1007/s00705-018-3 (via https://www.ncbi.nlm.nih.gov/pubmed/30066273)
The emergence of swine-origin pandemic H1N1 (pH1N1) in 2009 invigorated extensive surveillance programs worldwide which have resulted in the deposition of large numbers of H1N1 sequences to Genbank. In ...

Mondini G, etc.,al. Prospective cohort studies to evaluate the safety and immunogenicity of the 2013, 2014, and 2015 seasonal influenza vaccines produced by Instituto Butantan. Rev Inst Med Trop Sao Paulo. 2018 Jul 30;60:e37..  Abstract  
submitted by kickingbird at Aug, 5, 2018 from Rev Inst Med Trop Sao Paulo. 2018 Jul 30;60:e37. (via https://www.ncbi.nlm.nih.gov/pubmed/30066805)
Annual vaccination is the most effective way to prevent seasonal influenza illness. Instituto Butantan (IB) performed clinical studies with its 2013, 2014 and 2015 seasonal trivalent influenza vaccines ...

Kaitlyn Vette, Christina Bareja, Robert Clark & Ap. Establishing thresholds and parameters for pandemic influenza severity assessment, Australia. Bulletin of the World Health Organization Volume 9.  Abstract  
submitted by kickingbird at Aug, 2, 2018 from Bulletin of the World Health Organization Volume 9 (via http://www.who.int/bulletin/volumes/96/8/18-211508-ab/en/)
Objective To implement the World Health Organization’s pandemic influenza severity assessment tool in Australia, using multiple sources of data to establish thresholds and measure influenza severity indicators. Methods We ...

Tachibana M, etc.,al. Clasmatodendrosis is associated with dendritic spines and does not represent autophagic astrocyte death in influenza-associated encephalopathy. Brain Dev. 2018 Jul 26. pii: S0387-7604(18)30099-8.  Abstract  
submitted by kickingbird at Aug, 2, 2018 from Brain Dev. 2018 Jul 26. pii: S0387-7604(18)30099-8 (via https://www.ncbi.nlm.nih.gov/pubmed/30057207)
BACKGROUND: Influenza-associated encephalopathy (IAE) is one of the most serious CNS complications of an influenza virus infection, with unclear pathophysiology. Clasmatodendrosis is a complex of morphological ...

Han A, Poon JL, Powers JH 3rd, Leidy NK, Yu R. Using the Influenza Patient-reported Outcome (FLU-PRO) diary to evaluate symptoms of influenza viral infection in a healthy human challenge model. BMC Infect Dis. 2018 Jul 28;18(1):353.  Abstract  
submitted by kickingbird at Aug, 2, 2018 from BMC Infect Dis. 2018 Jul 28;18(1):353 (via https://www.ncbi.nlm.nih.gov/pubmed/30055573)
BACKGROUND: In clinical studies involving a healthy volunteer human challenge model, a valid and reliable measure to assess the evolution of patient-reported symptom type and severity following viral exposure ...

Paireau J, etc.,al. Mapping influenza activity in emergency departments in France using Bayesian model-based geostatistics. Influenza Other Respir Viruses. 2018 Jul 28..  Abstract  
submitted by kickingbird at Aug, 2, 2018 from Influenza Other Respir Viruses. 2018 Jul 28. (via https://www.ncbi.nlm.nih.gov/pubmed/30055089)
BACKGROUND: Maps of influenza activity are important tools to monitor influenza epidemics and inform policymakers. In France, the availability of a high-quality dataset from the Oscour? surveillance network, ...

Mena J, etc.,al. Re-emergence of H3N8 Equine Influenza A virus in Chile, 2018. Transbound Emerg Dis. 2018 Jul 28.  Abstract  
submitted by kickingbird at Aug, 2, 2018 from Transbound Emerg Dis. 2018 Jul 28 (via https://www.ncbi.nlm.nih.gov/pubmed/30054993)
A new outbreak of equine Influenza A virus (IAV) was reported in Chile in January 2018, six years after its last report in 2012. Equine IAV was detected by rtRT-PCR, followed by virus isolation and full ...

Machado A, etc.,al. Factors associated to repeated influenza vaccination in the Portuguese adults with chronic conditions. Vaccine. 2018 Jul 24. pii: S0264-410X(18)31010-7..  Abstract  
submitted by kickingbird at Aug, 2, 2018 from Vaccine. 2018 Jul 24. pii: S0264-410X(18)31010-7. (via https://www.ncbi.nlm.nih.gov/pubmed/30054159)
Annual influenza vaccination is recommended to people with chronic conditions. This study aimed to estimate the proportion of chronically ill adults vaccinated against influenza in consecutive seasons ...

Dal Negro RW, Turco P, Povero M. Cost of influenza and influenza-like syndromes (I-LSs) in Italy: Results of a cross-sectional telephone survey on a representative sample of general population. Respir Med. 2018 Aug;141:144-149.  Abstract  
submitted by kickingbird at Aug, 2, 2018 from Respir Med. 2018 Aug;141:144-149 (via https://www.ncbi.nlm.nih.gov/pubmed/30053960)
OBJECTIVES: Influenza and Influenza-like syndromes (I-LSs) are very common events in general practice, and their relevance is frequently underestimated. Aim of the study was to assess the economic impact ...

Tapia R, García V, Mena J, Bucarey S, Medina. Infection of novel reassortant H1N2 and H3N2 swine influenza A viruses in the guinea pig model. Vet Res. 2018 Jul 27;49(1):73..  Abstract  
submitted by kickingbird at Aug, 2, 2018 from Vet Res. 2018 Jul 27;49(1):73. (via https://www.ncbi.nlm.nih.gov/pubmed/30053826)
Novel H1N2 and H3N2 swine influenza A viruses (IAVs) were identified in commercial farms in Chile. These viruses contained H1, H3 and N2 sequences, genetically divergent from IAVs described worldwide, ...

Diefenbacher M, Sun J, Brooke CB. The parts are greater than the whole: the role of semi-infectious particles in influenza A virus biology. Curr Opin Virol. 2018 Jul 24;33:42-46.  Abstract  
submitted by kickingbird at Aug, 2, 2018 from Curr Opin Virol. 2018 Jul 24;33:42-46 (via https://www.ncbi.nlm.nih.gov/pubmed/30053722)
The influenza A virus (IAV) genome is incorporated into newly produced virions through a tightly orchestrated process that is one of the best studied examples of genome packaging by a segmented virus. ...

Guo Z, Wilson JR, York IA, Stevens J. Biosensor-based epitope mapping of antibodies targeting the hemagglutinin and neuraminidase of influenza A virus. J Immunol Methods. 2018 Jul 24. pii: S0022-1759(17.  Abstract  
submitted by kickingbird at Aug, 2, 2018 from J Immunol Methods. 2018 Jul 24. pii: S0022-1759(17 (via https://www.ncbi.nlm.nih.gov/pubmed/30053389)
Characterization of the epitopes on antigen recognized by monoclonal antibodies (mAb) is useful for the development of therapeutic antibodies, diagnostic tools, and vaccines. Epitope mapping also provides ...

Cocoros NM, etc.,al. Outpatient influenza antivirals in a distributed data network for influenza surveillance. Influenza Other Respir Viruses. 2018 Jul 27.  Abstract  
submitted by kickingbird at Aug, 2, 2018 from Influenza Other Respir Viruses. 2018 Jul 27 (via https://www.ncbi.nlm.nih.gov/pubmed/30053342)
Electronic data collected from routine healthcare can be used for public health surveillance. To examine the Sentinel System, a distributed data network of health plans, as a source for influenza surveillance, ...

Yogaratnam J, etc.,al. Antiviral Activity, Safety, and Pharmacokinetics of AL-794, a Novel Oral Influenza Endonuclease Inhibitor: Results of an Influenza Human Challenge Study. J Infect Dis. 2018 Jul 26..  Abstract  
submitted by kickingbird at Aug, 2, 2018 from J Infect Dis. 2018 Jul 26. (via https://www.ncbi.nlm.nih.gov/pubmed/30053042)
Background: AL-794 is an orally active prodrug of ALS-033719, which selectively inhibits the endonuclease domain of influenza virus A and B polymerase.Methods: In a phase 1, double-blinded, randomized, ...

Machablishvili A, etc.,al. Overview of three influenza seasons in Georgia, 2014-2017. PLoS One. 2018 Jul 27;13(7):e0201207.  Abstract  
submitted by kickingbird at Aug, 2, 2018 from PLoS One. 2018 Jul 27;13(7):e0201207 (via https://www.ncbi.nlm.nih.gov/pubmed/30052663)
BACKGROUND: Influenza epidemiological and virologic data from Georgia are limited. We aimed to present Influenza Like Illness (ILI) and Severe Acute Respiratory Infection (SARI) surveillance data and characterize ...

Szymański K, etc.,al. Infections with Influenza A/H3N2/ Subtype in Poland in the 2016/2017 Epidemic Season. Adv Exp Med Biol. 2018 Jul 27..  Abstract  
submitted by kickingbird at Aug, 2, 2018 from Adv Exp Med Biol. 2018 Jul 27. (via https://www.ncbi.nlm.nih.gov/pubmed/30051316)
The 2016/2017 epidemic season was characterized by a lower number of diagnostically tested samples of the nasal and throat swabs and bronchoalveolar lavage fluid, compared with the preceding season. The ...

Jasmina M. Luczo, etc.,al. Evolution of high pathogenicity of H5 avian influenza virus: haemagglutinin cleavage site selection of reverse-genetics mutants during passage in chickens. Scientific Reports volume 8, Article number: 1151.  Abstract  
submitted by kickingbird at Aug, 2, 2018 from Scientific Reports volume 8, Article number: 1151 (via https://www.nature.com/articles/s41598-018-29944-z)
Low pathogenicity avian influenza viruses (LPAIVs) are generally asymptomatic in their natural avian hosts. LPAIVs can evolve into highly pathogenic forms, which can affect avian and human populations ...

Kumar A, etc.,al. MicroRNA hsa-miR-324-5p Suppresses H5N1 Virus Replication by Targeting the Viral PB1 and Host CUEDC2. J Virol. 2018 Jul 25.  Abstract  
submitted by kickingbird at Jul, 29, 2018 from J Virol. 2018 Jul 25 (via https://www.ncbi.nlm.nih.gov/pubmed/30045983)
MicroRNAs (miRNAs) are small non-coding RNAs that are crucial post-transcriptional regulator for host mRNAs. Recent studies indicate that miRNAs may modulate host response during RNA viruses infection. ...

Nachbagauer R, Krammer F, Albrecht RA. A Live-Attenuated Prime, Inactivated Boost Vaccination Strategy with Chimeric Hemagglutinin-Based Universal Influenza Virus Vaccines Provides Protection in Ferrets: A Confirmatory Study. Vaccines (Basel). 2018 Jul 25;6(3)..  Abstract  
submitted by kickingbird at Jul, 29, 2018 from Vaccines (Basel). 2018 Jul 25;6(3). (via https://www.ncbi.nlm.nih.gov/pubmed/30044403)
Influenza viruses cause severe diseases and mortality in humans on an annual basis. The current influenza virus vaccines can confer protection when they are well-matched with the circulating strains. However, ...

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