Cross protective immunity against influenza A virus between subtypes induced by influenza polymerase protein PB1 in mice

To investigate the possibility of the influenza RNA polymerase proteins PB2 and PBl served as the alternative antigens of the experimental influenza vaccine. Methods The replicative DNA vaccines encoding the PB2 or PBl protein from different influenza viruses (A1/PR/8/34 and A3/jingke/95/30) were constructed respectively;the vaccine inoculated mice were attacked by influenza A virus(A/PR/8/34) through nasal pathway to see the protective efficiency of the replicative DNA vaccine. Results The replicative DNA ...

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