In late April, 2024, we detected a non-subtypeable influenza virus in a hospitalized patient, resident of the Metropolitan area of Mexico City. Our results using 5 complete viral segments M, NS, NA, NP and HA, showed identity of 99% with avian influenza A(H5N2) from Texcoco, Mexico of 2024. This case is the first with direct evidence of human infection caused by the H5N2 influenza virus, relationship with severity remain unknow.