We read with interest a recent letter in the Journal of Infection, which reported the emergence of novel H5N6 reassortant and it´s threat to both birds and humans. Pigs are susceptible to human, swine, and avian influenza A viruses (IAVs) and considered as intermediate hosts or “mixing vessels” for generating novel viruses with pandemic potential. Moreover, China has a complicated ecosystem of swine influenza viruses (SIVs) in which H1N1, H1N2, and H3N2 subtypes with classical swine (CS), North America triple-reassortant (TR), Eurasian avian-like (EA), and H1N1 pandemic/2009 (pdm/09) lineages are co-circulating throughout the swine population. This co-circulation has led to frequent emergence of novel reassortments or genotypes. In this study, we report a novel influenza virus A(H1N2) virus, A/swine/Henan/417/2021(H1N2) (HN/21) that was isolated from a swine farm in December 12, 2021 in Henan, China.