An influenza HA Computationally Optimized Broadly Reactive Antigen elicits antibodies endowed with group-1 heterosubtypic breadth against swine influenza viruses

Computationally Optimized Broadly Reactive Antigens (COBRA) designed for different influenza virus subtypes (H1N1, H3N2 and H5N1) elicit a subtype-specific broad antibody (Ab) response in na?ve as well as in pre-immune influenza virus animal models (1-9).….